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Just got an answer from Roche pharmacist
Well, I've been on Alli for about a year. Went up to 120 mg orlistat dose. I'm gaining weight back. The pharmacist said that your body does get used to the drug - so side effects will diminish, and I'm assuming efficacy as well. I'm thinking it does help you lose weight, but now I'm gaining weight back. So I'm not sure it's the answer for maintenance - what is!! I needed the "edge" or boost to lose at least some weight - I'm 55 and have an office job. I was a very fat baby. So there you go - I need to quit my job and spend my day at the health club and in the kitchen making salads!!
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